Promethazine Hydrochloride Injection
Brand names: Phenergan, Promethazine Hydrochloride
Category: Analgesia/Addiction, Gastroenterology, Other, Pediatric, Pulmonary/Allergy
FDA status: Current · Last FDA update: Sep 22, 2026 · First posted: Nov 21, 2023 (in shortage 2 years 10 months) · 2 manufacturers, 10 listed presentations
As of Sep 22, 2026, the FDA lists Promethazine Hydrochloride Injection as currently in shortage. Of 10 manufacturer presentations, 6 Unavailable, 1 Limited, 3 Available.
| Presentation & package NDC | Manufacturer | Availability | FDA note |
|---|---|---|---|
| Promethazine Hydrochloride, Injection, 25 mg/1 mL (NDC 0641-0928-25) NDC 0641-0928-25 |
Hikma Pharmaceuticals USA, Inc. | Unavailable | Additional lots will be available in the October 2026 timeframe. Product will be made available as it is released. |
| Phenergan, Injection, 25 mg/1 mL (NDC 0641-6082-25) NDC 0641-6082-25 |
Hikma Pharmaceuticals USA, Inc. | Unavailable | Additional lots are scheduled to be manufactured. Product will be made available as it is released. |
| Phenergan, Injection, 25 mg/1 mL (NDC 0641-6084-25) NDC 0641-6084-25 |
Hikma Pharmaceuticals USA, Inc. | Unavailable | Estimated recovery: TBD |
| Promethazine Hydrochloride, Injection, 25 mg/1 mL (NDC 0641-1495-35) NDC 0641-1495-35 |
Hikma Pharmaceuticals USA, Inc. | Available | Limited availability |
| Promethazine Hydrochloride, Injection, 25 mg/1 mL (NDC 39822-5525-3) NDC 39822-5525-3 |
XGen Pharmaceuticals DJB, Inc. | Available | - |
| Phenergan, Injection, 50 mg/1 mL (NDC 0641-6085-25) NDC 0641-6085-25 |
Hikma Pharmaceuticals USA, Inc. | Unavailable | Estimated recovery: TBD |
| Phenergan, Injection, 50 mg/1 mL (NDC 0641-6083-25) NDC 0641-6083-25 |
Hikma Pharmaceuticals USA, Inc. | Unavailable | Additional lots are scheduled to be manufactured. Product will be made available as it is released. |
| Promethazine Hydrochloride, Injection, 50 mg/1 mL (NDC 39822-5550-6) NDC 39822-5550-6 |
XGen Pharmaceuticals DJB, Inc. | Unavailable | Estimated recovery: TBD |
| Promethazine Hydrochloride, Injection, 50 mg/1 mL (NDC 0641-0929-25) NDC 0641-0929-25 |
Hikma Pharmaceuticals USA, Inc. | Limited | Estimated recovery: TBD |
| Promethazine Hydrochloride, Injection, 50 mg/1 mL (NDC 0641-1496-35) NDC 0641-1496-35 |
Hikma Pharmaceuticals USA, Inc. | Available | Additional lots are scheduled to be manufactured. Product will be made available as it is released. |
Related medications in shortage
Other Analgesia/Addiction, Gastroenterology, Other, Pediatric, Pulmonary/Allergy medications currently on the FDA shortage list — useful context if you and your prescriber are weighing alternatives. Always confirm with your pharmacist.
Change log
Tracking began Oct 1, 2026. We check the FDA every 6 hours; any real change - a manufacturer moving from Limited to Available, a new recovery date, a new listing - shows up here with its date.
Cite this: “FDA drug-shortage status for Promethazine Hydrochloride Injection (FDA data as of Sep 22, 2026). Shortage Watch, openFDA.”
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FDA data last synced Oct 1, 2026 (FDA record dated Sep 30, 2026).