Epinephrine Bitartrate, Lidocaine Hydrochloride Injection
Brand names: Xylocaine, Xylocaine Mpf
Category: Anesthesia, Pediatric
Unavailable 9Limited 3Available 10
FDA status: Current · Last FDA update: Sep 22, 2026 · First posted: Feb 22, 2012 (in shortage 14 years 7 months) · 2 manufacturers, 22 listed presentations
As of Sep 22, 2026, the FDA lists Epinephrine Bitartrate, Lidocaine Hydrochloride Injection as currently in shortage. Of 22 manufacturer presentations, 9 Unavailable, 3 Limited, 10 Available.
Ask your pharmacist: which of the 2 manufacturers below can they order right now, and whether a different strength or form of Epinephrine Bitartrate, Lidocaine Hydrochloride Injection is available. For alternatives, talk to your prescriber — see what to do if your medication is in shortage.
| Presentation & package NDC | Manufacturer | Availability | FDA note |
|---|---|---|---|
| Lidocaine Hydrochloride And Epinephrine, Injection, 250 mg/50 mL (0.5%; 1:200,000) (NDC 0409-3177-01) NDC 0409-3177-01 |
Hospira, Inc., a Pfizer Company | Unavailable | Next Delivery and Estimated Recovery: December 2026; Shortage per Manufacturer: Manufacturing Delay |
| Lidocaine Hydrochloride And Epinephrine, Injection, 75 mg/5 mL (1.5%; 1:200,000) (NDC 0409-1209-01) NDC 0409-1209-01 |
Hospira, Inc., a Pfizer Company | Unavailable | Next Delivery: November 2026; Estimated Recovery: December 2026; Shortage per Manufacturer: Manufacturing Delay |
| Lidocaine Hydrochloride And Epinephrine, Injection, 400 mg/20 mL (2%; 1:100,000) (NDC 0409-3182-01) NDC 0409-3182-01 |
Hospira, Inc., a Pfizer Company | Unavailable | Next Delivery and Estimated Recovery: December 2028; Shortage per Manufacturer: Manufacturing Delay |
| Lidocaine Hydrochloride And Epinephrine, Injection, 200 mg/20 mL (1%; 1:100,000) (NDC 0409-3178-01) NDC 0409-3178-01 |
Hospira, Inc., a Pfizer Company | Unavailable | Next Delivery: October 2026; Estimated Recovery: December 2026; Shortage per Manufacturer: Manufacturing Delay |
| Lidocaine Hydrochloride And Epinephrine, Injection, 300 mg/30 mL (1%; 1:100,000) (NDC 0409-3178-02) NDC 0409-3178-02 |
Hospira, Inc., a Pfizer Company | Unavailable | Next Delivery: November 2026; Estimated Recovery: June 2027; Shortage per Manufacturer: Manufacturing Delay |
| Lidocaine Hydrochloride and Epinephrine, Injection, 600 mg/30 mL (2%; 1:100,000) (NDC 0409-3182-02) NDC 0409-3182-02 |
Hospira, Inc., a Pfizer Company | Limited | Limited Supply Available. Next Delivery: May 2027; Estimated Recovery: June 2027; Shortage per Manufacturer: Manufacturing Delay |
| Lidocaine Hydrochloride And Epinephrine, Injection, 1 g/50 mL (2%; 1:100,000) (NDC 0409-3182-03) NDC 0409-3182-03 |
Hospira, Inc., a Pfizer Company | Limited | Limited Supply Available. Next Delivery: May 2027; Estimated Recovery: June 2027; Shortage per Manufacturer: Manufacturing Delay |
| Lidocaine Hydrochloride And Epinephrine, Injection, 500 mg/50 mL (1%; 1:100,000) (NDC 0409-3178-03) NDC 0409-3178-03 |
Hospira, Inc., a Pfizer Company | Limited | Limited Supply Available. Next Delivery: May 2027; Estimated Recovery: June 2027; Shortage per Manufacturer: Manufacturing Delay |
| Lidocaine Hydrochloride And Epinephrine, Injection, 450 mg/30 mL (1.5%; 1:200,000) (NDC 0409-3181-01) NDC 0409-3181-01 |
Hospira, Inc., a Pfizer Company | Available | - |
| Lidocaine Hydrochloride And Epinephrine, Injection, 400 mg/20 mL (2%; 1:200,000) (NDC 0409-3183-01) NDC 0409-3183-01 |
Hospira, Inc., a Pfizer Company | Available | - |
| Xylocaine, Injection, .005 mg/1 mL; 10 mg/1 mL (NDC 63323-487-17) NDC 63323-487-17 |
Fresenius Kabi USA, LLC | Available | Check wholesalers for inventory |
| Xylocaine, Injection, .005 mg/1 mL; 10 mg/1 mL (NDC 63323-487-37) NDC 63323-487-37 |
Fresenius Kabi USA, LLC | Available | Check wholesalers for inventory |
| Xylocaine, Injection, .005 mg/1 mL; 15 mg/1 mL (NDC 63323-488-17) NDC 63323-488-17 |
Fresenius Kabi USA, LLC | Unavailable | Next release September 2026. Check wholesalers for inventory. |
| Xylocaine, Injection, .005 mg/1 mL; 15 mg/1 mL (NDC 63323-488-37) NDC 63323-488-37 |
Fresenius Kabi USA, LLC | Available | Check wholesalers for inventory |
| Xylocaine, Injection, .005 mg/1 mL; 20 mg/1 mL (NDC 63323-489-27) NDC 63323-489-27 |
Fresenius Kabi USA, LLC | Unavailable | Next release September 2026. Check wholesalers for inventory. |
| Xylocaine, Injection, .005 mg/1 mL; 20 mg/1 mL (NDC 63323-489-17) NDC 63323-489-17 |
Fresenius Kabi USA, LLC | Available | Check wholesalers for inventory |
| Xylocaine, Injection, .005 mg/1 mL; 5 mg/1 mL (NDC 63323-481-57) NDC 63323-481-57 |
Fresenius Kabi USA, LLC | Unavailable | Next release September 2026. Check wholesalers for inventory. |
| Xylocaine, Injection, .01 mg/1 mL; 10 mg/1 mL (NDC 63323-482-57) NDC 63323-482-57 |
Fresenius Kabi USA, LLC | Unavailable | Next release September 2026. Check wholesalers for inventory. |
| Xylocaine, Injection, .01 mg/1 mL; 10 mg/1 mL (NDC 63323-482-27) NDC 63323-482-27 |
Fresenius Kabi USA, LLC | Available | Check wholesalers for inventory |
| Xylocaine, Injection, .01 mg/1 mL; 10 mg/1 mL (NDC 63323-482-17) NDC 63323-482-17 |
Fresenius Kabi USA, LLC | Available | Check wholesalers for inventory |
| Xylocaine, Injection, .01 mg/1 mL; 20 mg/1 mL (NDC 63323-483-57) NDC 63323-483-57 |
Fresenius Kabi USA, LLC | Available | Check wholesalers for inventory |
| Xylocaine, Injection, .01 mg/1 mL; 20 mg/1 mL (NDC 63323-483-27) NDC 63323-483-27 |
Fresenius Kabi USA, LLC | Available | Check wholesalers for inventory |
Related medications in shortage
Other Anesthesia, Pediatric medications currently on the FDA shortage list — useful context if you and your prescriber are weighing alternatives. Always confirm with your pharmacist.
Change log
No changes recorded yet.
Tracking began Oct 1, 2026. We check the FDA every 6 hours; any real change - a manufacturer moving from Limited to Available, a new recovery date, a new listing - shows up here with its date.
Tracking began Oct 1, 2026. We check the FDA every 6 hours; any real change - a manufacturer moving from Limited to Available, a new recovery date, a new listing - shows up here with its date.
Cite this: “FDA drug-shortage status for Epinephrine Bitartrate, Lidocaine Hydrochloride Injection (FDA data as of Sep 22, 2026). Shortage Watch, openFDA.”
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FDA data last synced Oct 1, 2026 (FDA record dated Sep 30, 2026).