Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection
Brand names: Bupivacaine Hydrochloride And Epinephrine, Marcaine With Epinephrine, Sensorcaine, Sensorcaine Mpf
Category: Anesthesia
FDA status: Current · Last FDA update: Sep 22, 2026 · First posted: Feb 20, 2018 (in shortage 8 years 7 months) · 2 manufacturers, 20 listed presentations
As of Sep 22, 2026, the FDA lists Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection as currently in shortage. Of 20 manufacturer presentations, 7 Unavailable, 13 Available.
| Presentation & package NDC | Manufacturer | Availability | FDA note |
|---|---|---|---|
| Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 25 mg/10 mL (2.5 mg/mL 1:200,000) (NDC 0409-1746-10) NDC 0409-1746-10 |
Hospira, Inc., a Pfizer Company | Available | - |
| Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 250 mg/50 mL (5 mg/mL 1:200,000) (NDC 0409-1755-50) NDC 0409-1755-50 |
Hospira, Inc., a Pfizer Company | Available | - |
| Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 75 mg/30 mL (2.5 mg/mL 1:200,000) (NDC 0409-1746-30) NDC 0409-1746-30 |
Hospira, Inc., a Pfizer Company | Available | - |
| Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 50 mg/10 mL (5 mg/mL 1:200,000) (NDC 0409-1749-10) NDC 0409-1749-10 |
Hospira, Inc., a Pfizer Company | Available | - |
| Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 150 mg/30 mL (5 mg/mL 1:200,000) (NDC 0409-1749-29) NDC 0409-1749-29 |
Hospira, Inc., a Pfizer Company | Available | - |
| Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 125 mg/50 mL (2.5 mg/mL 1:200,000) (NDC 0409-1752-50) NDC 0409-1752-50 |
Hospira, Inc., a Pfizer Company | Available | - |
| Sensorcaine, Injection, 2.5 mg/1 mL; .005 mg/1 mL (NDC 63323-468-17) NDC 63323-468-17 |
Fresenius Kabi USA, LLC | Available | Check wholesalers for inventory |
| Sensorcaine, Injection, 2.5 mg/1 mL; .005 mg/1 mL (NDC 63323-461-57) NDC 63323-461-57 |
Fresenius Kabi USA, LLC | Available | Check wholesaler for inventory |
| Sensorcaine, Injection, 2.5 mg/1 mL; .005 mg/1 mL (NDC 63323-468-37) NDC 63323-468-37 |
Fresenius Kabi USA, LLC | Available | Check wholesaler for inventory |
| Sensorcaine, Injection, 5 mg/1 mL; .005 mg/1 mL (NDC 63323-462-31) NDC 63323-462-31 |
Fresenius Kabi USA, LLC | Unavailable | Estimated recovery: TBD |
| Sensorcaine, Injection, 5 mg/1 mL; .005 mg/1 mL (NDC 63323-462-17) NDC 63323-462-17 |
Fresenius Kabi USA, LLC | Available | Check wholesalers for inventory |
| Sensorcaine, Injection, 5 mg/1 mL; .005 mg/1 mL (NDC 63323-463-57) NDC 63323-463-57 |
Fresenius Kabi USA, LLC | Available | Check wholesaler for inventory |
| Sensorcaine, Injection, 5 mg/1 mL; .005 mg/1 mL (NDC 63323-462-37) NDC 63323-462-37 |
Fresenius Kabi USA, LLC | Available | Check wholesalers for inventory |
| Sensorcaine, Injection, 7.5 mg/1 mL; .005 mg/1 mL (NDC 63323-460-37) NDC 63323-460-37 |
Fresenius Kabi USA, LLC | Available | Check wholesaler for inventory |
| Bupivacaine Hydrochloride and Epinephrine, Injection, 125 mg/50 mL (2.5 mg/mL) (NDC 0409-9043-01) NDC 0409-9043-01 |
Hospira, Inc., a Pfizer Company | Unavailable | Next Delivery and Estimated Recovery: December 2028; Shortage per Manufacturer: Manufacturing Delay |
| Bupivacaine Hydrochloride and Epinephrine, Injection, 150 mg/30 mL (5 mg/mL) (NDC 0409-9045-17) NDC 0409-9045-17 |
Hospira, Inc., a Pfizer Company | Unavailable | Next Delivery and Estimated Recovery: December 2028; Shortage per Manufacturer: Manufacturing Delay |
| Bupivacaine Hydrochloride And Epinephrine, Injection, 25 mg/10 mL (2.5 mg/mL) (NDC 0409-9042-01) NDC 0409-9042-01 |
Hospira, Inc., a Pfizer Company | Unavailable | Next Delivery and Estimated Recovery: December 2028; Shortage per Manufacturer: Manufacturing Delay |
| Bupivacaine Hydrochloride And Epinephrine, Injection, 250 mg/50 mL (5 mg/mL) (NDC 0409-9046-01) NDC 0409-9046-01 |
Hospira, Inc., a Pfizer Company | Unavailable | Next Delivery and Estimated Recovery: December 2028; Shortage per Manufacturer: Manufacturing Delay |
| Bupivacaine Hydrochloride And Epinephrine, Injection, 50 mg/10 mL (5 mg/mL) (NDC 0409-9045-01) NDC 0409-9045-01 |
Hospira, Inc., a Pfizer Company | Unavailable | Next Delivery and Estimated Recovery: December 2028; Shortage per Manufacturer: Manufacturing Delay |
| Bupivacaine Hydrochloride And Epinephrine, Injection, 75 mg/30 mL (2.5 mg/mL) (NDC 0409-9042-17) NDC 0409-9042-17 |
Hospira, Inc., a Pfizer Company | Unavailable | Next Delivery and Estimated Recovery: December 2028; Shortage per Manufacturer: Manufacturing Delay |
Related medications in shortage
Other Anesthesia medications currently on the FDA shortage list — useful context if you and your prescriber are weighing alternatives. Always confirm with your pharmacist.
Change log
Tracking began Oct 1, 2026. We check the FDA every 6 hours; any real change - a manufacturer moving from Limited to Available, a new recovery date, a new listing - shows up here with its date.
Cite this: “FDA drug-shortage status for Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection (FDA data as of Sep 22, 2026). Shortage Watch, openFDA.”
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FDA data last synced Oct 1, 2026 (FDA record dated Sep 30, 2026).